Altered Cofactor Preference of Thermostable StDAPDH by a Single Mutation at K159.

Gao, Xiuzhen; Ma, Qinyuan; Song, Huihui; Sun, Xinming; Li, Zhiyun; Liu, Mingfei

Gao, Xiuzhen; Ma, Qinyuan; Song, Huihui; Sun, Xinming; Li, Zhiyun; Liu, Mingfei.

Afiliação

Gao X; School of Life Science, Shandong University of Technology, Zibo 255000, China.
Ma Q; Key Laboratory of Industrial Fermentation, Ministry of Education, Tianjin Key Lab of IndustrialMicrobiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457,China.
Song H; School of Life Science, Shandong University of Technology, Zibo 255000, China.
Sun X; School of Life Science, Shandong University of Technology, Zibo 255000, China.
Li Z; School of Life Science, Shandong University of Technology, Zibo 255000, China.
Liu M; School of Life Science, Shandong University of Technology, Zibo 255000, China.

Int J Mol Sci ; 21(5)2020 Mar 05.

Article em En | MEDLINE | ID: mdl-32150965

Assuntos

Actinobacteria/enzimologia; Aminoácido Oxirredutases/genética; Aminoácido Oxirredutases/metabolismo; Mutação; NADP/metabolismo; NAD/metabolismo; Aminoácido Oxirredutases/química; Sítios de Ligação; Modelos Moleculares; Conformação Proteica; Especificidade por Substrato; Temperatura

Palavras-chave

D-amino acid; cofactor engineering; meso-diaminopimelate dehydrogenase; molecular dynamics simulations; thermostable enzyme

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Actinobacteria / Aminoácido Oxirredutases / Mutação / NAD / NADP Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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