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Cognitive function prior to systemic therapy and subsequent well-being in older breast cancer survivors: Longitudinal findings from the Thinking and Living with Cancer Study.
Kobayashi, Lindsay C; Cohen, Harvey Jay; Zhai, Wanting; Zhou, Xingtao; Small, Brent J; Luta, George; Hurria, Arti; Carroll, Judith; Tometich, Danielle; McDonald, Brenna C; Graham, Deena; Jim, Heather S L; Jacobsen, Paul; Root, James C; Saykin, Andrew J; Ahles, Tim A; Mandelblatt, Jeanne.
Afiliação
  • Kobayashi LC; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Cohen HJ; Center for the Study of Aging and Human Development, Duke University, Durham, North Carolina, USA.
  • Zhai W; Department of Oncology and Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
  • Zhou X; Department of Oncology and Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
  • Small BJ; School of Aging Studies, University of South Florida, Tampa, Florida, USA.
  • Luta G; Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA.
  • Hurria A; Department of Biostatistics, Bioinformatics, and Biomathematics and Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
  • Carroll J; Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA.
  • Tometich D; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
  • McDonald BC; Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA.
  • Graham D; Center for Neuroimaging, Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Jim HSL; Hackensack University Medical Center, Hackensack, New Jersey, USA.
  • Jacobsen P; Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA.
  • Root JC; Healthcare Delivery Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Shady, Maryland, USA.
  • Saykin AJ; Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
  • Ahles TA; Center for Neuroimaging, Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Mandelblatt J; Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Psychooncology ; 29(6): 1051-1059, 2020 06.
Article em En | MEDLINE | ID: mdl-32154959
OBJECTIVE: To investigate the relationships between self-reported and objectively measured cognitive function prior to systemic therapy and subsequent well-being outcomes over 24 months in older breast cancer survivors. METHODS: Data were from 397 women aged 60 to 98 diagnosed with non-metastatic breast cancer in the Thinking and Living with Cancer Study recruited from 2010-2016. Cognitive function was measured at baseline (following surgery, prior to systemic therapy) using neuropsychological assessments of attention, processing speed, and executive function (APE), learning and memory (LM), and the self-reported FACT-Cog scale. Well-being was measured using the FACT-G functional, physical, social, and emotional well-being domain scales at baseline and 12 and 24 months later, scaled from 0 (low) to 100 (high). Linear mixed-effects models assessed the relationships between each of baseline APE, LM, and FACT-Cog quartiles with well-being scores over 24 months, adjusted for confounding variables. RESULTS: At baseline, older survivors in the lowest APE, LM, and FACT-Cog score quartiles experienced poorer global well-being than those in the highest quartiles. At 24 months, older survivors tended to improve in well-being, and there were no differences according to baseline APE or LM scores. At 24 months, mean global well-being was 80.3 (95% CI: 76.2-84.3) among those in the lowest vs 86.6 (95% CI: 83.1-90.1) in the highest FACT-cog quartile, a clinically meaningful difference of 6.3 points (95% CI: 1.5-11.1). CONCLUSIONS: Among older breast cancer survivors, self-reported, but not objective cognitive impairments, were associated with lower global well-being over the first 2 years of survivorship.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Cognição / Autorrelato / Sobreviventes de Câncer Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Cognição / Autorrelato / Sobreviventes de Câncer Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article