Treatment of Dystrophic <i>mdx</i> Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles.

Addinsall, Alex B; Forgan, Leonard G; McRae, Natasha L; Kelly, Rhys W; McDonald, Penny L; McNeill, Bryony; McCulloch, Daniel R; Stupka, Nicole

Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles.

Addinsall, Alex B; Forgan, Leonard G; McRae, Natasha L; Kelly, Rhys W; McDonald, Penny L; McNeill, Bryony; McCulloch, Daniel R; Stupka, Nicole.

Afiliação

Addinsall AB; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.
Forgan LG; Department of Physiology and Pharmacology, Karolinska Insitutet, Stockholm 171 77, Sweden.
McRae NL; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.
Kelly RW; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.
McDonald PL; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.
McNeill B; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.
McCulloch DR; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.
Stupka N; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.

Biomolecules ; 10(3)2020 03 07.

Article em En | MEDLINE | ID: mdl-32156081

Assuntos

Proteína ADAMTS5/antagonistas & inibidores; Anticorpos Monoclonais/farmacologia; Fibras Musculares de Contração Rápida/metabolismo; Força Muscular/efeitos dos fármacos; Distrofia Muscular de Duchenne/metabolismo; Proteína ADAMTS5/metabolismo; Animais; Modelos Animais de Doenças; Membro Posterior/metabolismo; Membro Posterior/patologia; Camundongos; Camundongos Endogâmicos mdx; Fibras Musculares de Contração Rápida/patologia; Distrofia Muscular de Duchenne/patologia

Palavras-chave

ADAMTS-5; Duchenne muscular dystrophy; contractile function; desmin; mdx mouse; myogenesis; skeletal muscle; versican; versikine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibras Musculares de Contração Rápida / Distrofia Muscular de Duchenne / Força Muscular / Proteína ADAMTS5 / Anticorpos Monoclonais Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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