Targeting MYC through WDR5.
Mol Cell Oncol
; 7(2): 1709388, 2020.
Article
em En
| MEDLINE
| ID: mdl-32158922
ABSTRACT
The oncoprotein transcription factor MYC is overexpressed in most cancers and is responsible for hundreds of thousands of cancer deaths worldwide every year. MYC is also a highly validated - but currently undruggable - anti-cancer target. We recently showed that breaking the interaction of MYC with its chromatin co-factor WD repeat-containing protein 5 (WDR5) promotes tumor regression in mouse xenografts, laying the foundation for a new strategy to inhibit MYC in the clinic.
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MEDLINE
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En
Ano de publicação:
2020
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Article