Expression and function of cartilage-derived pluripotent cells in joint development and repair.
Stem Cell Res Ther
; 11(1): 111, 2020 03 12.
Article
em En
| MEDLINE
| ID: mdl-32160923
ABSTRACT
Cartilage-derived pluripotent cells reside in hyaline cartilage and fibrocartilage. These cells have the potential for multidirectional differentiation; can undergo adipogenesis, osteogenesis, and chondrogenesis; and have been classified as mesenchymal stem cells (MSCs) conforming to the minimal criteria of the International Society for Cellular Therapy. Cartilage tissue is prone to injury and is difficult to repair. As cartilage-derived pluripotent cells are the closest cell source to cartilage tissue, they are expected to have the strongest ability to differentiate into cartilage compared to other MSCs. This review focuses on the organizational distribution, expression, and function of cartilage-derived pluripotent cells in joint development and repair to help explore the therapeutic potential of in situ cartilage-derived pluripotent cells for joint cartilage repair.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cartilagem Articular
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Transplante de Células-Tronco Mesenquimais
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Células-Tronco Mesenquimais
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article