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Metabolic host response and therapeutic approaches to influenza infection.
Keshavarz, Mohsen; Solaymani-Mohammadi, Farid; Namdari, Haideh; Arjeini, Yaser; Mousavi, Mohammad Javad; Rezaei, Farhad.
Afiliação
  • Keshavarz M; 1The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
  • Solaymani-Mohammadi F; 2Department of Biological Sciences, North Dakota State University, Fargo, North Dakota USA.
  • Namdari H; 3Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Arjeini Y; 4Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Mousavi MJ; 5Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Rezaei F; 6Department of Immunology and Allergy, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Cell Mol Biol Lett ; 25: 15, 2020.
Article em En | MEDLINE | ID: mdl-32161622
ABSTRACT
Based on available metabolomic studies, influenza infection affects a variety of cellular metabolic pathways to ensure an optimal environment for its replication and production of viral particles. Following infection, glucose uptake and aerobic glycolysis increase in infected cells continually, which results in higher glucose consumption. The pentose phosphate shunt, as another glucose-consuming pathway, is enhanced by influenza infection to help produce more nucleotides, especially ATP. Regarding lipid species, following infection, levels of triglycerides, phospholipids, and several lipid derivatives undergo perturbations, some of which are associated with inflammatory responses. Also, mitochondrial fatty acid ß-oxidation decreases significantly simultaneously with an increase in biosynthesis of fatty acids and membrane lipids. Moreover, essential amino acids are demonstrated to decline in infected tissues due to the production of large amounts of viral and cellular proteins. Immune responses against influenza infection, on the other hand, could significantly affect metabolic pathways. Mainly, interferon (IFN) production following viral infection affects cell function via alteration in amino acid synthesis, membrane composition, and lipid metabolism. Understanding metabolic alterations required for influenza virus replication has revealed novel therapeutic methods based on targeted inhibition of these cellular metabolic pathways.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interferons / Metabolismo Energético / Indolamina-Pirrol 2,3,-Dioxigenase / Metabolismo dos Lipídeos / Influenza Humana / Glucose Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interferons / Metabolismo Energético / Indolamina-Pirrol 2,3,-Dioxigenase / Metabolismo dos Lipídeos / Influenza Humana / Glucose Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article