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A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor.
Chen, Wenbo; Boras, Britton; Sung, Tae; Yu, Yanke; Zheng, Jenny; Wang, Diane; Hu, Wenyue; Spilker, Mary E; D'Argenio, David Z.
Afiliação
  • Chen W; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA.
  • Boras B; Pfizer Worldwide Research, Development and Medicine, San Diego, CA, USA.
  • Sung T; Pfizer Worldwide Research, Development and Medicine, San Diego, CA, USA.
  • Yu Y; Pfizer Global Product Development, San Diego, CA, USA.
  • Zheng J; Pfizer Global Product Development, Collegeville, PA, USA.
  • Wang D; Pfizer Global Product Development, San Diego, CA, USA.
  • Hu W; Pfizer Worldwide Research, Development and Medicine, San Diego, CA, USA.
  • Spilker ME; Pfizer Worldwide Research, Development and Medicine, San Diego, CA, USA.
  • D'Argenio DZ; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA. dargenio@bmsr.usc.edu.
J Pharmacokinet Pharmacodyn ; 47(2): 163-182, 2020 04.
Article em En | MEDLINE | ID: mdl-32162138
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medula Óssea / Ciclo Celular / Granulócitos / Neutropenia Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medula Óssea / Ciclo Celular / Granulócitos / Neutropenia Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article