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Novel 1H-pyrazolo[3,4-d]pyrimidin-6-amino derivatives as potent selective Janus kinase 3 (JAK3) inhibitors. Evaluation of their improved effect for the treatment of rheumatoid arthritis.
Yin, Yuan; Chen, Cheng-Juan; Yu, Ru-Nan; Shu, Lei; Wang, Zhi-Jian; Zhang, Tian-Tai; Zhang, Da-Yong.
Afiliação
  • Yin Y; School of Science, China Pharmaceutical University, Nanjing, PR China.
  • Chen CJ; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
  • Yu RN; School of Science, China Pharmaceutical University, Nanjing, PR China.
  • Shu L; School of Science, China Pharmaceutical University, Nanjing, PR China.
  • Wang ZJ; School of Science, China Pharmaceutical University, Nanjing, PR China.
  • Zhang TT; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China. Electronic address: ttzhang@imm.ac.cn.
  • Zhang DY; School of Science, China Pharmaceutical University, Nanjing, PR China. Electronic address: cpuzdy@163.com.
Bioorg Chem ; 98: 103720, 2020 05.
Article em En | MEDLINE | ID: mdl-32171982
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Experimental / Artrite Reumatoide / Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Janus Quinase 3 Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Experimental / Artrite Reumatoide / Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Janus Quinase 3 Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article