Design, synthesis and biological evaluation of 4-(pyridin-4-yloxy)benzamide derivatives bearing a 5-methylpyridazin-3(2H)-one fragment.

Xiong, Hehua; Zhang, Jianqing; Zhang, Qian; Duan, Yongli; Zhang, Han; Zheng, Pengwu; Tang, Qidong

Xiong, Hehua; Zhang, Jianqing; Zhang, Qian; Duan, Yongli; Zhang, Han; Zheng, Pengwu; Tang, Qidong.

Afiliação

Xiong H; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China.
Zhang J; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China.
Zhang Q; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China.
Duan Y; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China; School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu 610054, PR C
Zhang H; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China.
Zheng P; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China. Electronic address: zhengpw@126.com.
Tang Q; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Bioorg Med Chem Lett ; 30(9): 127076, 2020 05 01.

Article em En | MEDLINE | ID: mdl-32173195

Assuntos

Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Benzamidas/síntese química; Benzamidas/farmacologia; Desenho de Fármacos; Antineoplásicos/química; Benzamidas/química; Domínio Catalítico; Linhagem Celular Tumoral; Sobrevivência Celular; Humanos; Concentração Inibidora 50; Modelos Moleculares; Estrutura Molecular; Conformação Proteica; Proteínas Proto-Oncogênicas c-met/química; Relação Estrutura-Atividade

Palavras-chave

4-(Pyridin-4-yloxy)benzamide derivatives; 5-Methylpyridazin-3(2H)-one; Inhibitors; Synthesis; c-Met

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidas / Desenho de Fármacos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google