Pathogen-Associated Molecular Pattern-Induced TLR2 and TLR4 Activation Increases Keratinocyte Production of Inflammatory Mediators and is Inhibited by Phosphatidylglycerol.

Choudhary, Vivek; Griffith, Shantelle; Chen, Xunsheng; Bollag, Wendy B

Choudhary, Vivek; Griffith, Shantelle; Chen, Xunsheng; Bollag, Wendy B.

Afiliação

Choudhary V; Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia (V.C., W.B.B.); and Departments of Physiology (V.C., S.G., X.C., W.B.B.) and Dermatology (W.B.B.), Medical College of Georgia at Augusta University, Augusta, Georgia.
Griffith S; Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia (V.C., W.B.B.); and Departments of Physiology (V.C., S.G., X.C., W.B.B.) and Dermatology (W.B.B.), Medical College of Georgia at Augusta University, Augusta, Georgia.
Chen X; Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia (V.C., W.B.B.); and Departments of Physiology (V.C., S.G., X.C., W.B.B.) and Dermatology (W.B.B.), Medical College of Georgia at Augusta University, Augusta, Georgia.
Bollag WB; Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia (V.C., W.B.B.); and Departments of Physiology (V.C., S.G., X.C., W.B.B.) and Dermatology (W.B.B.), Medical College of Georgia at Augusta University, Augusta, Georgia wbollag@augusta.edu.

Mol Pharmacol ; 97(5): 324-335, 2020 05.

Article em En | MEDLINE | ID: mdl-32173651

Assuntos

Mediadores da Inflamação/metabolismo; Queratinócitos/metabolismo; Moléculas com Motivos Associados a Patógenos/farmacologia; Fosfatidilgliceróis/farmacologia; Receptor 2 Toll-Like/metabolismo; Receptor 4 Toll-Like/metabolismo; Animais; Calgranulina B/farmacologia; Humanos; Imidazóis/farmacologia; Lipopeptídeos/farmacologia; Lipopolissacarídeos/farmacologia; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Camundongos; NF-kappa B/metabolismo; Células RAW 264.7; Receptores de Reconhecimento de Padrão/metabolismo; Proteínas Recombinantes/farmacologia; Glycine max/química

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilgliceróis / Queratinócitos / Mediadores da Inflamação / Receptor 2 Toll-Like / Receptor 4 Toll-Like / Moléculas com Motivos Associados a Patógenos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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