Stp1 Loss of Function Promotes ß-Lactam Resistance in Staphylococcus aureus That Is Independent of Classical Genes.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Article
em En
| MEDLINE
| ID: mdl-32179529
ABSTRACT
ß-Lactam resistance in Staphylococcus aureus limits treatment options. Stp1 and Stk1, a serine-threonine phosphatase and kinase, respectively, mediate serine-threonine kinase (STK) signaling. Loss-of-function point mutations in stp1 were detected among laboratory-passaged ß-lactam-resistant S. aureus strains lacking mecA and blaZ, the major determinants of ß-lactam resistance in the bacteria. Loss of Stp1 function facilitates ß-lactam resistance of the bacteria.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
/
Staphylococcus aureus Resistente à Meticilina
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article