Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities.

Noh, Hyangsoon; Lee, Sung Jun; Jo, Hyun-Joo; Choi, Hye Won; Hong, Sungguan; Kong, Kwang-Hoon

Noh, Hyangsoon; Lee, Sung Jun; Jo, Hyun-Joo; Choi, Hye Won; Hong, Sungguan; Kong, Kwang-Hoon.

Afiliação

Noh H; Department of Chemistry, College of Natural Sciences, Chung-Ang University, Seoul, South Korea.
Lee SJ; Department of Chemistry, College of Natural Sciences, Chung-Ang University, Seoul, South Korea.
Jo HJ; Department of Chemistry, College of Natural Sciences, Chung-Ang University, Seoul, South Korea.
Choi HW; Department of Chemistry, College of Natural Sciences, Chung-Ang University, Seoul, South Korea.
Hong S; Department of Chemistry, College of Natural Sciences, Chung-Ang University, Seoul, South Korea.
Kong KH; Department of Chemistry, College of Natural Sciences, Chung-Ang University, Seoul, South Korea.

J Enzyme Inhib Med Chem ; 35(1): 726-732, 2020 Dec.

Article em En | MEDLINE | ID: mdl-32180482

Assuntos

Cobre/metabolismo; Histidina/metabolismo; Monofenol Mono-Oxigenase/metabolismo; Sequência de Aminoácidos; Sítios de Ligação; Biocatálise; Cobre/química; Histidina/química; Humanos; Cinética; Modelos Moleculares; Monofenol Mono-Oxigenase/química; Monofenol Mono-Oxigenase/genética; Mutagênese Sítio-Dirigida; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Alinhamento de Sequência

Palavras-chave

CuA and CuB binding site; Human tyrosinase; active site; histidine residues; site-directed mutagenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Monofenol Mono-Oxigenase / Cobre / Histidina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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