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The impact of the ancillary pilus-1 protein RrgA of Streptococcus pneumoniae on colonization and disease.
Iovino, Federico; Nannapaneni, Priyanka; Henriques-Normark, Birgitta; Normark, Staffan.
Afiliação
  • Iovino F; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Nannapaneni P; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Henriques-Normark B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Normark S; Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
Mol Microbiol ; 113(3): 650-658, 2020 03.
Article em En | MEDLINE | ID: mdl-32185835
ABSTRACT
The Gram-positive bacterium Streptococcus pneumoniae, the pneumococcus, is an important commensal resident of the human nasopharynx. Carriage is usually asymptomatic, however, S. pneumoniae can become invasive and spread from the upper respiratory tract to the lungs causing pneumonia, and to other organs to cause severe diseases such as bacteremia and meningitis. Several pneumococcal proteins important for its disease-causing capability have been described and many are expressed on the bacterial surface. The surface located pneumococcal type-1 pilus has been associated with virulence and the inflammatory response, and it is present in 20%-30% of clinical isolates. Its tip protein RrgA has been shown to be a major adhesin to human cells and to promote invasion through the blood-brain barrier. In this review we discuss recent findings of the impact of RrgA on bacterial colonization of the upper respiratory tract and on pneumococcal virulence, and use epidemiological data and genome-mining to suggest trade-off mechanisms potentially explaining the rather low prevalence of pilus-1 expressing pneumococci in humans.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pneumoniae / Proteínas de Fímbrias / Fatores de Virulência Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pneumoniae / Proteínas de Fímbrias / Fatores de Virulência Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article