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Absence of FGFR3-TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration.
Banella, C; Ginevrino, M; Catalano, G; Fabiani, E; Falconi, G; Divona, M; Curzi, P; Panetta, P; Voso, M T; Noguera, N I.
Afiliação
  • Banella C; Neuro-oncohematology Unit, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
  • Ginevrino M; Neurogenetics Unit, IRCCS Santa Lucia Foundation, Rome, Italy; Deparment of Molecular Medicine, University of Pavia, Pavia, Italy.
  • Catalano G; Neuro-oncohematology Unit, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
  • Fabiani E; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
  • Falconi G; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
  • Divona M; Policlinico Tor Vergata, Rome, Italy.
  • Curzi P; Policlinico Tor Vergata, Rome, Italy.
  • Panetta P; Policlinico Tor Vergata, Rome, Italy.
  • Voso MT; Neuro-oncohematology Unit, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
  • Noguera NI; Neuro-oncohematology Unit, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. Electronic address: n.noguera@hsantalucia.it.
Hematol Oncol Stem Cell Ther ; 14(2): 163-168, 2021 Jun.
Article em En | MEDLINE | ID: mdl-32199932
ABSTRACT
FGFR-TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR-TACC fusions are present in many hematological disorders and there are no data on the prevalence, we studied a series of patients with acute myeloid leukemia and myelodysplastic syndrome who presented numerical alterations using cytogenetic traditional analysis. None of the analyzed samples showed FGFR3-TACC3 gene fusion, so screening for this mutation at diagnosis is not recommended.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Leucemia Mieloide Aguda / Proteínas de Fusão Oncogênica / Receptor Tipo 3 de Fator de Crescimento de Fibroblastos / Proteínas Associadas aos Microtúbulos Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Leucemia Mieloide Aguda / Proteínas de Fusão Oncogênica / Receptor Tipo 3 de Fator de Crescimento de Fibroblastos / Proteínas Associadas aos Microtúbulos Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article