Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration.

Liu, Jun; Hong, Junshik; Han, Heejoo; Park, Jihyun; Kim, Dongchan; Park, Hyejoo; Ko, Myunggon; Koh, Youngil; Shin, Dong-Yeop; Yoon, Sung-Soo

Liu, Jun; Hong, Junshik; Han, Heejoo; Park, Jihyun; Kim, Dongchan; Park, Hyejoo; Ko, Myunggon; Koh, Youngil; Shin, Dong-Yeop; Yoon, Sung-Soo.

Afiliação

Liu J; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Hong J; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. alertjun@hanmail.net.
Han H; Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. alertjun@hanmail.net.
Park J; Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. alertjun@hanmail.net.
Kim D; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Park H; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Ko M; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Koh Y; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Shin DY; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Yoon SS; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

Br J Cancer ; 122(10): 1445-1452, 2020 05.

Article em En | MEDLINE | ID: mdl-32203209

Assuntos

Ácido Ascórbico/metabolismo; Proteínas de Ligação a DNA/genética; Transportador de Glucose Tipo 3/genética; Leucemia Mieloide Aguda/genética; Proteínas Proto-Oncogênicas/genética; Ácido Ascórbico/genética; Biomarcadores Tumorais/genética; Dioxigenases; Progressão da Doença; Feminino; Regulação Neoplásica da Expressão Gênica/genética; Humanos; Leucemia Mieloide Aguda/metabolismo; Leucemia Mieloide Aguda/patologia; Masculino; Análise em Microsséries; Intervalo Livre de Progressão

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas / Proteínas de Ligação a DNA / Transportador de Glucose Tipo 3 Limite: Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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