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A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer.
Ma, Danhui; Zou, Yutian; Chu, Yunxiang; Liu, Zhengsheng; Liu, Gaochao; Chu, Jun; Li, Mengdi; Wang, Jiayu; Sun, Shi-Yong; Chang, Zhijie.
Afiliação
  • Ma D; State Key Laboratory of Membrane Biology, School of Medicine, National Engineering Laboratory for Anti-tumor Therapeutics, Tsinghua University, Beijing 100084, China.
  • Zou Y; State Key Laboratory of Membrane Biology, School of Medicine, National Engineering Laboratory for Anti-tumor Therapeutics, Tsinghua University, Beijing 100084, China.
  • Chu Y; College of Letters and Science, University of California, Berkeley, 101 Durant Hall, Berkeley, CA 94720.
  • Liu Z; Department of Gastroenterology, Emergency General Hospital, Beijing 100028, China.
  • Liu G; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
  • Chu J; MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, 100084 China.
  • Li M; State Key Laboratory of Membrane Biology, School of Medicine, National Engineering Laboratory for Anti-tumor Therapeutics, Tsinghua University, Beijing 100084, China.
  • Wang J; State Key Laboratory of Membrane Biology, School of Medicine, National Engineering Laboratory for Anti-tumor Therapeutics, Tsinghua University, Beijing 100084, China.
  • Sun SY; State Key Laboratory of Membrane Biology, School of Medicine, National Engineering Laboratory for Anti-tumor Therapeutics, Tsinghua University, Beijing 100084, China.
  • Chang Z; Department of Hematology and Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Theranostics ; 10(8): 3708-3721, 2020.
Article em En | MEDLINE | ID: mdl-32206117
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Peptídeos / Regulação Neoplásica da Expressão Gênica / Proteínas de Ciclo Celular / Proteólise / Proteínas de Neoplasias Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Peptídeos / Regulação Neoplásica da Expressão Gênica / Proteínas de Ciclo Celular / Proteólise / Proteínas de Neoplasias Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article