PGRMC1 in animal breast cancer tissue and blood is associated with increased tumor growth with norethisterone in contrast to progesterone and dydrogesterone: four-arm randomized placebo-controlled xenograft study.

Cai, Guiju; Ruan, Xiangyan; Gu, Muqing; Zhao, Yue; Wang, Yuejiao; Mueck, Alfred O

Cai, Guiju; Ruan, Xiangyan; Gu, Muqing; Zhao, Yue; Wang, Yuejiao; Mueck, Alfred O.

Afiliação

Cai G; Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Ruan X; Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Gu M; University Women's Hospital and Research Centre for Women's Health, Department of Women's Health, University of Tuebingen, Tuebingen, Germany.
Zhao Y; Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Wang Y; Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Mueck AO; Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Gynecol Endocrinol ; 36(11): 1024-1027, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32208774

Assuntos

Proliferação de Células/efeitos dos fármacos; Didrogesterona/farmacologia; Neoplasias Mamárias Experimentais/patologia; Proteínas de Membrana/metabolismo; Noretindrona/farmacologia; Progesterona/farmacologia; Receptores de Progesterona/metabolismo; Animais; Biomarcadores Tumorais/sangue; Biomarcadores Tumorais/metabolismo; Linhagem Celular Tumoral; Feminino; Xenoenxertos; Humanos; Células MCF-7; Glândulas Mamárias Animais/efeitos dos fármacos; Glândulas Mamárias Animais/metabolismo; Glândulas Mamárias Animais/patologia; Neoplasias Mamárias Experimentais/sangue; Neoplasias Mamárias Experimentais/metabolismo; Proteínas de Membrana/sangue; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Transplante de Neoplasias; Placebos; Distribuição Aleatória; Receptores de Progesterona/sangue

Palavras-chave

Mouse xenograft model; blood PGRMC1; breast-tumor growth; progestogens; tissue PGRMC1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Progesterona / Receptores de Progesterona / Proliferação de Células / Didrogesterona / Neoplasias Mamárias Experimentais / Proteínas de Membrana / Noretindrona Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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