Subcutaneous sumatriptan reduces cilostazol induced headache in migraine patients.
Cephalalgia
; 40(8): 842-850, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32216457
ABSTRACT
OBJECTIVES:
The authors have previously tried to develop a model for the testing of novel drug candidates for migraine, using the headache and migraine provoking agent cilostazol. Previous studies have used sumatriptan tablets as the validating drug, but they were not sufficiently effective. In this study we test the effect of subcutaneous sumatriptan on cilostazol induced headache in patients with migraine without aura.METHOD:
Thirty patients with migraine without aura received 200 mg cilostazol on two different study days. The induced headache was treated with subcutaneous sumatriptan in a randomized, double-blind cross-over design. The patients filled out a self-reported headache questionnaire until 12 h after cilostazol.RESULTS:
All 30 patients experienced headache (range 3-10) on both study days and the headache fulfilled the criteria for a migraine-like attack in 73% on the sumatriptan day and in 77% on the placebo day. Sumatriptan injection reduced the headache score 2 h after treatment (p = 0.003). The difference between headache intensity on the sumatriptan day and the placebo day was significant at both 2 h (p = 0.01) and 4 h (p = 0.0007) after treatment.CONCLUSION:
Subcutaneous sumatriptan reduces cilostazol induced headache in migraine patients. The cilostazol model may be useful as a tool to test the potential of new anti-migraine drugs.Trial registration The study is registered on clinicaltrials.gov (NCT03422796).Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vasodilatadores
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Sumatriptana
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Agonistas do Receptor 5-HT1 de Serotonina
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Cilostazol
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Transtornos de Enxaqueca
Tipo de estudo:
Clinical_trials
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Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article