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Solidago virgaurea L. Plant Extract Targeted Against Candida albicans to Reduce Oral Microbial Biomass: a Double Blind Randomized Trial on Healthy Adults.
Prêcheur, Isabelle; Rolland, Yohan; Hasseine, Lilia; Orange, François; Morisot, Adeline; Landreau, Anne.
Afiliação
  • Prêcheur I; Université Nice Côte d'Azur, Faculté de Chirurgie Dentaire, Laboratoire Micoralis EA 7354, 06300 Nice, France.
  • Rolland Y; Université Nice Côte d'Azur, Centre Hospitalier Universitaire, Pôle Odontologie, 06200 Nice, France.
  • Hasseine L; Givaudan, Naturex, 84140 Avignon, France.
  • Orange F; Université Nice Côte d'Azur, Centre Hospitalier Universitaire, Laboratoire de Parasitologie-Mycologie, 06200 Nice, France.
  • Morisot A; Université Nice Côte d'Azur, Faculté des Sciences, Centre Commun de Microscopie Appliquée (CCMA), 06000 Nice, France.
  • Landreau A; Université Nice Côte d'Azur, Centre Hospitalier Universitaire, Département de Santé Publique, 06200 Nice, France.
Antibiotics (Basel) ; 9(4)2020 Mar 25.
Article em En | MEDLINE | ID: mdl-32218125
Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, Candida albicans. It reduces the biomass of Candida-bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group n = 33 vs. control n = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), C. albicans and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28 p = 0.005 and ΔD14D28 p = 0.026), Streptococcus mutans (ΔD0D14 p = 0.024) and C. albicans (ΔD0D28 p = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28 p = 0.062 and ΔD14D28 p = 0.009). Plaque Index and Gingival Index improved in both groups.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Ano de publicação: 2020 Tipo de documento: Article