Adeno-Associated Virus D-Sequence-Mediated Suppression of Expression of a Human Major Histocompatibility Class II Gene: Implications in the Development of Adeno-Associated Virus Vectors for Modulating Humoral Immune Response.

Kwon, Hyung-Joo; Qing, Keyun; Ponnazhagan, Selvarangan; Wang, Xu-Shan; Markusic, David M; Gupte, Siddhant; Boye, Shannon E; Srivastava, Arun

Kwon, Hyung-Joo; Qing, Keyun; Ponnazhagan, Selvarangan; Wang, Xu-Shan; Markusic, David M; Gupte, Siddhant; Boye, Shannon E; Srivastava, Arun.

Afiliação

Kwon HJ; Department of Microbiology, Hallym University College of Medicine, Chuncheon, South Korea.
Qing K; Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA.
Ponnazhagan S; Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Wang XS; Eli Lilly & Company, Indianapolis, Indiana, USA.
Markusic DM; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Gupte S; Department of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida, USA.
Boye SE; Department of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida, USA.
Srivastava A; Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA.

Hum Gene Ther ; 31(9-10): 565-574, 2020 05.

Article em En | MEDLINE | ID: mdl-32220217

Assuntos

Dependovirus/genética; Antígenos de Histocompatibilidade Classe II/genética; Imunidade Humoral; Sequências Repetidas Terminais; Animais; DNA Viral; Regulação para Baixo; Regulação da Expressão Gênica; Genes MHC da Classe II; Terapia Genética; Vetores Genéticos; Células HEK293; Antígenos HLA/genética; Células HeLa; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Regiões Promotoras Genéticas; Fator Regulador X1/genética; Homologia de Sequência

Palavras-chave

AAV; MHC class II; gene expression; gene therapy; immune response

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe II / Dependovirus / Sequências Repetidas Terminais / Imunidade Humoral Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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