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Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.
Laurent, Anouchka P; Siret, Aurélie; Ignacimouttou, Cathy; Panchal, Kunjal; Diop, M'Boyba; Jenni, Silvia; Tsai, Yi-Chien; Roos-Weil, Damien; Aid, Zakia; Prade, Nais; Lagarde, Stephanie; Plassard, Damien; Pierron, Gaelle; Daudigeos, Estelle; Lecluse, Yann; Droin, Nathalie; Bornhauser, Beat C; Cheung, Laurence C; Crispino, John D; Gaudry, Muriel; Bernard, Olivier A; Macintyre, Elizabeth; Barin Bonnigal, Carole; Kotecha, Rishi S; Geoerger, Birgit; Ballerini, Paola; Bourquin, Jean-Pierre; Delabesse, Eric; Mercher, Thomas; Malinge, Sebastien.
Afiliação
  • Laurent AP; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.
  • Siret A; Université Paris Diderot, Paris, France.
  • Ignacimouttou C; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.
  • Panchal K; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.
  • Diop M; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.
  • Jenni S; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France.
  • Tsai YC; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.
  • Roos-Weil D; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.
  • Aid Z; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.
  • Prade N; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.
  • Lagarde S; Centre of Research on Cancer of Toulouse (CRCT), CHU Toulouse, Université Toulouse III, Toulouse, France.
  • Plassard D; Centre of Research on Cancer of Toulouse (CRCT), CHU Toulouse, Université Toulouse III, Toulouse, France.
  • Pierron G; IGBMC, Plateforme GenomEast, UMR7104 CNRS, Ilkirch, France.
  • Daudigeos E; Service de Génétique, Institut Curie, Paris, France.
  • Lecluse Y; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France.
  • Droin N; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France.
  • Bornhauser BC; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.
  • Cheung LC; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.
  • Crispino JD; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.
  • Gaudry M; School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Australia.
  • Bernard OA; Division of Hematology/Oncology, Northwestern University, Chicago, Illinois.
  • Macintyre E; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.
  • Barin Bonnigal C; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.
  • Kotecha RS; Hematology, Université de Paris, Institut Necker-Enfants Malades and Assistance Publique-Hopitaux de Paris, Paris, France.
  • Geoerger B; Centre Hospitalier Universitaire de Tours, Tours, France.
  • Ballerini P; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.
  • Bourquin JP; School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Australia.
  • Delabesse E; Department of Clinical Haematology, Oncology and Bone Marrow Transplantation, Perth Children's Hospital, Perth, Australia.
  • Mercher T; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France.
  • Malinge S; Laboratoire d'Hématologie, Hôpital Trousseau, APHP, Paris-Sorbonne, Paris, France.
Clin Cancer Res ; 26(13): 3307-3318, 2020 07 01.
Article em En | MEDLINE | ID: mdl-32220889
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia de Células B / Transdução de Sinais / Síndrome de Down / Proteínas ras / Proteínas Quinases Ativadas por Mitógeno Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia de Células B / Transdução de Sinais / Síndrome de Down / Proteínas ras / Proteínas Quinases Ativadas por Mitógeno Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article