Intestinal resident macrophages: Multitaskers of the gut.
Neurogastroenterol Motil
; 32(8): e13843, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32222060
ABSTRACT
BACKGROUND:
Intestinal resident macrophages play a crucial role in homeostasis and have been implicated in numerous gastrointestinal diseases. While historically believed to be largely of hematopoietic origin, recent advances in fate-mapping technology have unveiled the existence of long-lived, self-maintaining populations located in specific niches throughout the gut wall. Furthermore, the advent of single-cell technology has enabled an unprecedented characterization of the functional specialization of tissue-resident macrophages throughout the gastrointestinal tract.PURPOSE:
The purpose of this review was to provide a panorama on intestinal resident macrophages, with particular focus to the recent advances in the field. Here, we discuss the functions and phenotype of intestinal resident macrophages and, where possible, the functional specialization of these cells in response to the niche they occupy. Furthermore, we will discuss their role in gastrointestinal diseases.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gastroenteropatias
/
Intestinos
/
Macrófagos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article