Presence of Promyelocytes in Peripheral Blood as a Novel Predictor of Optimal Timing for Single-Step Peripheral Blood Stem Cell Collection.
J Nippon Med Sch
; 88(1): 45-53, 2021 Mar 11.
Article
em En
| MEDLINE
| ID: mdl-32238739
ABSTRACT
BACKGROUND:
Because peripheral blood stem cell (PBSC) collection places a burden on the patient and should ideally be completed in a single procedure, a convenient clinical predictive factor is needed.METHODS:
This retrospective study included 72 patients who underwent autologous PBSC collection. A median volume of 3.9 × 106 CD34-positive cells/kg (range 0.3-47.4 × 106 cells/kg) was collected on the first day. We defined failure as inability to collect 2.0 × 106 cells/kg on the first day. PBSC collection was classified as failed (n = 25, 34.7%) and successful (n = 47, 65.3%), and patient clinical characteristics were analyzed.RESULTS:
The success group had significantly more cases in which a differential white blood cell count in peripheral blood on the day of PBSC collection detected promyelocytes (n = 34 [72.3%] vs. n = 11 [44.0%] in the failure group; P = 0.008). Sixty-two patients underwent autologous PBSC transplantation (median number of transplanted cells, 5.6 × 106/µL; range 1.60-47.4 × 106 cells/µL). Among transplanted patients, the success and failure groups did not significantly differ in relation to the interval until neutrophil, platelet, or red blood cell engraftment.CONCLUSION:
The presence of promyelocytes in peripheral blood may be a useful indicator of the optimal timing for single-step PBSC collection.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante Autólogo
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Coleta de Tecidos e Órgãos
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Transplante de Células-Tronco de Sangue Periférico
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Células Precursoras de Granulócitos
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Células-Tronco de Sangue Periférico
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article