Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens.
Eur J Clin Microbiol Infect Dis
; 39(9): 1771-1779, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32242313
ABSTRACT
Pentamidine sensitizes FDA-approved antibiotics to combat Gram-negative pathogens. We screened 1374 FDA-approved non-antibiotics for their ability to be sensitized by pentamidine against Escherichia coli. We identified mitomycin C and mefloquine as potent hits effective against multiple drug-resistant, Gram-negative bacteria. Killing kinetics and an in vivo model with Caenorhabditis elegans (C. elegans) revealed that such combinations produced synergy against colistin-resistant Enterobacter cloacae (E. cloacae). These findings suggest combinations of FDA-approved non-antibiotics, and pentamidine can be repurposed into new antimicrobial agents.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pentamidina
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Infecções por Bactérias Gram-Negativas
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Bactérias Gram-Negativas
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Antibacterianos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article