Degeneration of Lumbar Intervertebral Discs: Characterization of Anulus Fibrosus Tissue and Cells of Different Degeneration Grades.

Stich, Stefan; Jagielski, Michal; Fleischmann, Anja; Meier, Carola; Bussmann, Patricia; Kohl, Benjamin; Schmidt, Julia; Krüger, Jan-Philipp; Endres, Michaela; Cabraja, Mario; Reimann, Kolja; Laue, Dominik; Ertel, Wolfgang; Sittinger, Michael

Stich, Stefan; Jagielski, Michal; Fleischmann, Anja; Meier, Carola; Bussmann, Patricia; Kohl, Benjamin; Schmidt, Julia; Krüger, Jan-Philipp; Endres, Michaela; Cabraja, Mario; Reimann, Kolja; Laue, Dominik; Ertel, Wolfgang; Sittinger, Michael.

Afiliação

Stich S; Department of Traumatology and Reconstructive Surgery, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany.
Jagielski M; Department of Traumatology and Reconstructive Surgery, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany.
Fleischmann A; Tissue Engineering Laboratory, BIH Center for Regenerative Therapies, and Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.
Meier C; Department of Traumatology and Reconstructive Surgery, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany.
Bussmann P; Department of Traumatology and Reconstructive Surgery, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany.
Kohl B; Department of Traumatology and Reconstructive Surgery, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany.
Schmidt J; Department of Spinal Surgery, Vivantes Auguste-Viktoria-Hospital, 12157 Berlin, Germany.
Krüger JP; Research and Development Department, TransTissue Technologies GmbH, 10117 Berlin, Germany.
Endres M; Research and Development Department, TransTissue Technologies GmbH, 10117 Berlin, Germany.
Cabraja M; Department of Spinal Surgery, Vivantes Auguste-Viktoria-Hospital, 12157 Berlin, Germany.
Reimann K; Department of Traumatology and Reconstructive Surgery, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany.
Laue D; Department of Traumatology and Reconstructive Surgery, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany.
Ertel W; Department of Traumatology and Reconstructive Surgery, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany.
Sittinger M; Tissue Engineering Laboratory, BIH Center for Regenerative Therapies, and Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.

Int J Mol Sci ; 21(6)2020 Mar 21.

Article em En | MEDLINE | ID: mdl-32245213

Assuntos

Anel Fibroso/metabolismo; Matriz Extracelular/metabolismo; Regulação da Expressão Gênica/genética; Degeneração do Disco Intervertebral/metabolismo; Deslocamento do Disco Intervertebral/metabolismo; Disco Intervertebral/metabolismo; Anel Fibroso/patologia; Proteína Morfogenética Óssea 2/farmacologia; Células Cultivadas; Matriz Extracelular/genética; Perfilação da Expressão Gênica; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Disco Intervertebral/patologia; Degeneração do Disco Intervertebral/genética; Degeneração do Disco Intervertebral/patologia; Deslocamento do Disco Intervertebral/genética; Deslocamento do Disco Intervertebral/patologia; Metaloproteinase 1 da Matriz/genética; Metaloproteinase 1 da Matriz/metabolismo; Metaloproteinase 13 da Matriz/genética; Metaloproteinase 13 da Matriz/metabolismo; Metaloproteinase 3 da Matriz/genética; Metaloproteinase 3 da Matriz/metabolismo; Análise de Sequência com Séries de Oligonucleotídeos; Regeneração/efeitos dos fármacos; Regeneração/genética; Fator de Crescimento Transformador beta1/farmacologia; Fator de Necrose Tumoral alfa/farmacologia

Palavras-chave

anulus fibrosus; degeneration; genome-wide microarray; intervertebral disc

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Matriz Extracelular / Degeneração do Disco Intervertebral / Anel Fibroso / Disco Intervertebral / Deslocamento do Disco Intervertebral Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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