Immuno-hematologic parameters following rodent spinal cord contusion are negatively influenced by high-fat diet consumption.
J Neuroimmunol
; 343: 577226, 2020 06 15.
Article
em En
| MEDLINE
| ID: mdl-32247229
ABSTRACT
Spinal cord injury (SCI) results in perturbations to the immune system leading to increased infection susceptibility. In parallel, the consumption of high-fat diets (HFD) leads to a chronic inflammation in circulation and body tissues. We investigated the impact of 16 weeks of HFD on chronically-injured rats. SCI rats under both chow and HFD showed peripheral leukocyte changes that include reduced percentages of total, helper and cytotoxic T, and natural killer cells. Expression of immune-related genes in the spleen and thymus reflected the impact of both chronic injury and diet. Changes to the immune system following SCI are adversely impacted by HFD consumption.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
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Baço
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Timo
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Linfócitos T
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Dieta Hiperlipídica
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article