Primary cilia control glucose homeostasis via islet paracrine interactions.

Hughes, Jing W; Cho, Jung Hoon; Conway, Hannah E; DiGruccio, Michael R; Ng, Xue Wen; Roseman, Henry F; Abreu, Damien; Urano, Fumihiko; Piston, David W

Hughes, Jing W; Cho, Jung Hoon; Conway, Hannah E; DiGruccio, Michael R; Ng, Xue Wen; Roseman, Henry F; Abreu, Damien; Urano, Fumihiko; Piston, David W.

Afiliação

Hughes JW; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110; jing.hughes@wustl.edu.
Cho JH; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Conway HE; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
DiGruccio MR; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.
Ng XW; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.
Roseman HF; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Abreu D; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Urano F; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Piston DW; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.

Proc Natl Acad Sci U S A ; 117(16): 8912-8923, 2020 04 21.

Article em En | MEDLINE | ID: mdl-32253320

Assuntos

Cílios/metabolismo; Diabetes Mellitus/patologia; Glucose/metabolismo; Células Secretoras de Insulina/metabolismo; Insulina/metabolismo; Animais; Cálcio/metabolismo; Comunicação Celular/fisiologia; Cílios/genética; Cílios/patologia; Diabetes Mellitus/genética; Modelos Animais de Doenças; Metabolismo Energético/fisiologia; Feminino; Células Secretoras de Glucagon/metabolismo; Humanos; Secreção de Insulina; Células Secretoras de Insulina/citologia; Células Secretoras de Insulina/patologia; Masculino; Camundongos; Camundongos Knockout; Transdução de Sinais/fisiologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cílios / Diabetes Mellitus / Células Secretoras de Insulina / Glucose / Insulina Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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