ADAM, a disintegrin and metalloproteinase with thrombospondin motifs; ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9; CLIC3, Chloride Intracellular Channel 3; CTGF, Connective Tissue Growth Factor; DEGs, differentially expressed genes; DMSO, dimethyl sulfoxide; ECM, extracellular matrix; EGCG, epigallocatechin gallate; EMT, epithelial to mesenchymal transition; Epigallocatechin gallate; FIS, fisetin; Fisetin; GO, Gene Ontology; Gene Ontology; HCC, hepatocellular carcinoma; HSPA2, Heat Shock Protein Family A (Hsp70) Member 2; HSPB1, Heat Shock Protein Family B (Small) Member 1; Hepatocellular carcinoma; MEM, minimum essential medium; MMP11, Matrix Metallopeptidase 11; MMP9, Matrix Metallopeptidase 9; MMPs, matrix metalloproteinases; PDGFRB, Platelet Derived Growth Factor Receptor Beta; RNA-sequencing; RT-qPCR, reverse transcription-quantitative real time PCR; Reactome Pathways; SD, standard deviation; SEM, standard error of mean; SERPINE1, Serpin Family E Member 1; STIM, stimulated; TF, transcription factor; Transcription factors