RNA-seq data analysis of stimulated hepatocellular carcinoma cells treated with epigallocatechin gallate and fisetin reveals target genes and action mechanisms.
Comput Struct Biotechnol J
; 18: 686-695, 2020.
Article
em En
| MEDLINE
| ID: mdl-32257052
ADAM, a disintegrin and metalloproteinase with thrombospondin motifs; ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9; CLIC3, Chloride Intracellular Channel 3; CTGF, Connective Tissue Growth Factor; DEGs, differentially expressed genes; DMSO, dimethyl sulfoxide; ECM, extracellular matrix; EGCG, epigallocatechin gallate; EMT, epithelial to mesenchymal transition; Epigallocatechin gallate; FIS, fisetin; Fisetin; GO, Gene Ontology; Gene Ontology; HCC, hepatocellular carcinoma; HSPA2, Heat Shock Protein Family A (Hsp70) Member 2; HSPB1, Heat Shock Protein Family B (Small) Member 1; Hepatocellular carcinoma; MEM, minimum essential medium; MMP11, Matrix Metallopeptidase 11; MMP9, Matrix Metallopeptidase 9; MMPs, matrix metalloproteinases; PDGFRB, Platelet Derived Growth Factor Receptor Beta; RNA-sequencing; RT-qPCR, reverse transcription-quantitative real time PCR; Reactome Pathways; SD, standard deviation; SEM, standard error of mean; SERPINE1, Serpin Family E Member 1; STIM, stimulated; TF, transcription factor; Transcription factors
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2020
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