5-methyl-THF, 5-methyltetrahydofolate; Agl, amylo-alpha-1,6-glucosidase,4-alpha-glucanotransferase gene; BCA, bicinchoninic acid; Bhmt, betaine-homocysteine S-methyltransferase gene; CE, cholesteryl-ester; Cebpa, CCAAT/enhancer binding protein (C/EBP), alpha gene; Cer, ceramide; DAG, diacylglycerol; Ddit3, DNA damage inducible transcript 3 gene; ETS, electron transport system; FCCP, p-trifluoromethoxyphenyl hydrazine; FFA, free fatty acid; G6pc, glucose 6-phophastase gene; Gbe1, glycogen branching enzyme 1 gene; Glycogen; Gsk3, glycogen synthase kinase gene; Gyg, glycogenin gene; Gys2, glycogen synthase 2 gene; HOAD, 3-hydoxyacyl-CoA dehydrogenase; Hepatic fuel storage; Isca1, iron­sulfur cluster assembly 1 gene; JO2, oxygen flux; LC-MS, liquid chromatography-mass spectrometry; LPC, lysophosphatidylcholine; Lipidomics; Liver metabolism; Mitochondrial function; Mthfr, methylenetetrahydrofolate reductase gene; Mtr, methionine synthase gene (also MS); Mtrr, methionine synthase reductase gene (also MSR); Myc, myelocytomatosis oncogene; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; Ndufs, NADH:ubiquinone oxidoreductase core subunit (ETS complex I) gene; OXPHOS, oxidative phosphorylation; One­carbon metabolism; PA, phosphatidic acid; PAS, periodic acid Schiff; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PG, phosphatidylglycerol; PI, phosphatidylinositol; PIP, phosphatidylinositol phosphate(s); PL, phospholipid; PS, phosphatidylserine; RIPA, Radioimmunoprecipitation assay; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; SM, sphingomyelin; TAG, triacylglycerol; Ugp2, UDP-glucose pyrophophorylase 2 gene; gt, gene-trap