NGS Evaluation of Colorectal Cancer Reveals Interferon Gamma Dependent Expression of Immune Checkpoint Genes and Identification of Novel IFNÎ³ Induced Genes.

Xu, Lai; Pelosof, Lorraine; Wang, Rong; McFarland, Hugh I; Wu, Wells W; Phue, Je-Nie; Lee, Chun-Ting; Shen, Rong-Fong; Juhl, Hartmut; Wu, Lei-Hong; Alterovitz, Wei-Lun; Petricon, Emanuel; Rosenberg, Amy S

Xu, Lai; Pelosof, Lorraine; Wang, Rong; McFarland, Hugh I; Wu, Wells W; Phue, Je-Nie; Lee, Chun-Ting; Shen, Rong-Fong; Juhl, Hartmut; Wu, Lei-Hong; Alterovitz, Wei-Lun; Petricon, Emanuel; Rosenberg, Amy S.

Afiliação

Xu L; Office of Oncologic Diseases, Center for Drug Evaluation and Research (CDER), FDA, Silver Spring, MD, United States.
Pelosof L; Office of Oncologic Diseases, Center for Drug Evaluation and Research (CDER), FDA, Silver Spring, MD, United States.
Wang R; Office of Biotechnology Products, Division of Biotechnology Review and Research III (DBRRIII), Office of Pharmaceutical Quality (OPQ), Center for Drug Evaluation and Research (CDER), FDA, Silver Spring, MD, United States.
McFarland HI; Office of Biotechnology Products, Division of Biotechnology Review and Research III (DBRRIII), Office of Pharmaceutical Quality (OPQ), Center for Drug Evaluation and Research (CDER), FDA, Silver Spring, MD, United States.
Wu WW; Facility for Biotechnology Resources, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, United States.
Phue JN; Facility for Biotechnology Resources, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, United States.
Lee CT; Facility for Biotechnology Resources, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, United States.
Shen RF; Facility for Biotechnology Resources, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, United States.
Juhl H; Indivumed GmbH, Hamburg, Germany.
Wu LH; Division of Bioinformatics and Biostatistics (DBB), National Center for Toxicological Research (NCTR), FDA, Jefferson, AR, United States.
Alterovitz WL; HIVE, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, United States.
Petricon E; Center for Applied Proteomics and Molecular Medicine (CAPMM), George Mason University, Fairfax, VA, United States.
Rosenberg AS; Office of Biotechnology Products, Division of Biotechnology Review and Research III (DBRRIII), Office of Pharmaceutical Quality (OPQ), Center for Drug Evaluation and Research (CDER), FDA, Silver Spring, MD, United States.

Front Immunol ; 11: 224, 2020.

Article em En | MEDLINE | ID: mdl-32265897

Assuntos

Neoplasias da Mama/genética; Colo/fisiologia; Neoplasias Colorretais/genética; Interferon gama/metabolismo; Melanoma/genética; Neoplasias Cutâneas/genética; Neoplasias Gástricas/genética; Neoplasias da Mama/imunologia; Neoplasias da Mama/mortalidade; Neoplasias Colorretais/imunologia; Neoplasias Colorretais/mortalidade; Feminino; Proteínas de Ligação ao GTP/genética; Proteínas de Ligação ao GTP/metabolismo; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Proteínas de Checkpoint Imunológico/genética; Masculino; Melanoma/imunologia; Oxirredutases atuantes sobre Doadores de Grupo Enxofre/genética; Oxirredutases atuantes sobre Doadores de Grupo Enxofre/metabolismo; Prognóstico; Neoplasias Cutâneas/imunologia; Neoplasias Gástricas/imunologia; Neoplasias Gástricas/mortalidade; Análise de Sobrevida; Melanoma Maligno Cutâneo

Palavras-chave

IFNÎ³ gradient; co-expression network; colorectal cancer; immune checkpoint genes; novel immune checkpoint related genes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Neoplasias Gástricas / Neoplasias da Mama / Neoplasias Colorretais / Interferon gama / Colo / Melanoma Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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