Water-Compatible Cycloadditions of Oligonucleotide-Conjugated Strained Allenes for DNA-Encoded Library Synthesis.

Westphal, Matthias V; Hudson, Liam; Mason, Jeremy W; Pradeilles, Johan A; Zécri, Frédéric J; Briner, Karin; Schreiber, Stuart L

Westphal, Matthias V; Hudson, Liam; Mason, Jeremy W; Pradeilles, Johan A; Zécri, Frédéric J; Briner, Karin; Schreiber, Stuart L.

Afiliação

Westphal MV; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States.
Hudson L; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Mason JW; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States.
Pradeilles JA; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Zécri FJ; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States.
Briner K; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States.

J Am Chem Soc ; 142(17): 7776-7782, 2020 04 29.

Article em En | MEDLINE | ID: mdl-32267148

Assuntos

Alcadienos/química; Reação de Cicloadição/métodos; Biblioteca Gênica; Oligonucleotídeos/metabolismo; Bibliotecas de Moléculas Pequenas/química; Humanos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Biblioteca Gênica / Alcadienos / Bibliotecas de Moléculas Pequenas / Reação de Cicloadição Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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