MAP6 is an intraluminal protein that induces neuronal microtubules to coil.
Sci Adv
; 6(14): eaaz4344, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32270043
ABSTRACT
Neuronal activities depend heavily on microtubules, which shape neuronal processes and transport myriad molecules within them. Although constantly remodeled through growth and shrinkage events, neuronal microtubules must be sufficiently stable to maintain nervous system wiring. This stability is somehow maintained by various microtubule-associated proteins (MAPs), but little is known about how these proteins work. Here, we show that MAP6, previously known to confer cold stability to microtubules, promotes growth. More unexpectedly, MAP6 localizes in the lumen of microtubules, induces the microtubules to coil into a left-handed helix, and forms apertures in the lattice, likely to relieve mechanical stress. These features have not been seen in microtubules before and could play roles in maintaining axonal width or providing flexibility in the face of compressive forces during development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Associadas aos Microtúbulos
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article