Treating Field Cancerization by Ablative Fractional Laser and Indoor Daylight: Assessment of Efficacy and Tolerability.
J Drugs Dermatol
; 19(4): 425-427, 2020 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-32272521
ABSTRACT
Objective:
To assess if ablative fractional laser combined with indoor daylight photodynamic therapy are effective and safe for the treatment of skin field cancerization associated with actinic keratosis (AK).Methods:
A total of 46 patients with field cancerized skin and AK were treated by a single session of laser assisted drug delivery (LAAD) and indoor daylight photodynamic therapy (IDL-PDT). LAAD was applied using a CO2 ablative fractional laser (AFXL) and aminolevulonic acid. Thereafter, IDL-PDT was administered using a novel device that mimics the sun radiation with a total dose of 48 J/cm².Results:
All patients showed remission following subsequent to the study protocol (complete 71.7%, partial 28.3%). Pain scores using a visual analog scare immediately following treatments were 9.0 ± 2.0.Conclusions:
AFXL-LAAD combined with IDL-PDT is extremely effective for the treatment of skin field cancerization associated with AK. Nevertheless, the high pain scores associated with this combined approach may prove to be a limiting factor. Thus, further protocol modifications in larger scale studies are still warranted. J Drugs Dermatol. 2020;19(3)425-427. doi10.36849/JDD.2020.4589.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Fármacos Fotossensibilizantes
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Lasers de Gás
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Ceratose Actínica
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Ácido Aminolevulínico
Tipo de estudo:
Guideline
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Observational_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article