A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma.

Ando, Hidenori; Saito-Tarashima, Noriko; Lila, Amr S Abu; Kinjo, Nozomi; Shimizu, Taro; Ishima, Yu; Minakawa, Noriaki; Ishida, Tatsuhiro

Ando, Hidenori; Saito-Tarashima, Noriko; Lila, Amr S Abu; Kinjo, Nozomi; Shimizu, Taro; Ishima, Yu; Minakawa, Noriaki; Ishida, Tatsuhiro.

Afiliação

Ando H; Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
Saito-Tarashima N; Department of Bioorganic Chemistry, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
Lila ASA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Kinjo N; Department of Pharmaceutics, College of Pharmacy, Hail University, Hail 81442, Saudi Arabia.
Shimizu T; Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
Ishima Y; Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
Minakawa N; Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
Ishida T; Department of Bioorganic Chemistry, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.

Molecules ; 25(7)2020 Apr 09.

Article em En | MEDLINE | ID: mdl-32283709

Assuntos

Inativação Gênica; Imunomodulação/genética; Mesotelioma Maligno/genética; Neoplasias Pleurais/genética; Interferência de RNA; Animais; Linhagem Celular Tumoral; Modelos Animais de Doenças; Expressão Gênica; Humanos; Imunidade Inata/genética; Lipossomos; Camundongos; RNA Interferente Pequeno/administração & dosagem; RNA Interferente Pequeno/genética; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

RNA interference; cationic liposomes; innate immunity; intelligent RNA expression device (iRed); shRNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pleurais / Inativação Gênica / Interferência de RNA / Imunomodulação / Mesotelioma Maligno Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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