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A novel Golgi mannosidase inhibitor: Molecular design, synthesis, enzyme inhibition, and inhibition of spheroid formation.
Koyama, Ryosuke; Kano, Yui; Kikushima, Kaori; Mizutani, Ayaka; Soeda, Yuta; Miura, Kazuki; Hirano, Takako; Nishio, Toshiyuki; Hakamata, Wataru.
Afiliação
  • Koyama R; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
  • Kano Y; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
  • Kikushima K; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
  • Mizutani A; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
  • Soeda Y; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
  • Miura K; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
  • Hirano T; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
  • Nishio T; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
  • Hakamata W; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan. Electronic address: hakamata.wataru@nihon-u.ac.jp.
Bioorg Med Chem ; 28(11): 115492, 2020 06 01.
Article em En | MEDLINE | ID: mdl-32291147
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Esferoides Celulares / Inibidores Enzimáticos / Complexo de Golgi / Manosidases Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Esferoides Celulares / Inibidores Enzimáticos / Complexo de Golgi / Manosidases Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article