Mechanisms and consequences of subcellular RNA localization across diverse cell types.
Traffic
; 21(6): 404-418, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32291836
ABSTRACT
Essentially all cells contain a variety of spatially restricted regions that are important for carrying out specialized functions. Often, these regions contain specialized transcriptomes that facilitate these functions by providing transcripts for localized translation. These transcripts play a functional role in maintaining cell physiology by enabling a quick response to changes in the cellular environment. Here, we review how RNA molecules are trafficked within cells, with a focus on the subcellular locations to which they are trafficked, mechanisms that regulate their transport and clinical disorders associated with misregulation of the process.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA
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Transporte de RNA
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Transcriptoma
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article