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Role of epoxyeicosatrienoic acids in the lung.
Olivares-Rubio, Hugo F; Espinosa-Aguirre, J J.
Afiliação
  • Olivares-Rubio HF; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ap. Postal 70-228, Ciudad de México, México. Electronic address: hugolivares@yahoo.com.mx.
  • Espinosa-Aguirre JJ; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ap. Postal 70-228, Ciudad de México, México. Electronic address: jjea99@gmail.com.
Prostaglandins Other Lipid Mediat ; 149: 106451, 2020 08.
Article em En | MEDLINE | ID: mdl-32294527
ABSTRACT
Epoxyeicosatrienoic acids (EETs) are synthetized from arachidonic acid by the action of members of the CYP2C and CYP2J subfamilies of cytochrome P450 (CYPs). The effects of EETs on cardiovascular function, the nervous system, the kidney and metabolic disease have been reviewed. In the lungs, the presence of these CYPs and EETs has been documented. In general, EETs play a beneficial role in this essential tissue. Among the most important effects of EETs in the lungs are the induction of vasorelaxation in the bronchi, the stimulation of Ca2+-activated K+ channels, the induction of vasoconstriction of pulmonary arteries, anti-inflammatory effects induced by asthma, and protection against infection or exposure to chemical substances such as cigarette smoke. EETs also participate in tissue regeneration, but on the downside, they are possibly involved in the progression of lung cancer. More research is necessary to design therapies with EETs for the treatment of lung disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido 8,11,14-Eicosatrienoico / Pulmão Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido 8,11,14-Eicosatrienoico / Pulmão Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article