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Plasma levels of polychlorinated biphenyl, genetic polymorphisms, and the risk of advanced stage endometriosis.
Kim, Miran; Kim, Sung Hoon; Kim, Hyun Jin; Whang, Dong Hee; Yun, Sung-Cheol; Lee, Sa Ra; Chae, Hee Dong; Kang, Byung Moon.
Afiliação
  • Kim M; Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
  • Kim SH; Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Kim HJ; Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Whang DH; Departments of Laboratory Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, South Korea.
  • Yun SC; Division of Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Lee SR; Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Chae HD; Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Kang BM; Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Gynecol Endocrinol ; 36(7): 636-640, 2020 Jul.
Article em En | MEDLINE | ID: mdl-32295439
ABSTRACT
Both environmental and genetic factors interact and play a critical role in the pathogenesis of endometriosis. We analyzed the plasma levels of 12 polychlorinated biphenyl (PCB) congeners with genetic polymorphisms of glutathione-S-transferase M1 (GSTM1), glutathione-S-transferase T1 (GSTT1), and aryl hydrocarbon receptor repressor (AhRR) codon 185. Total sum of the 12 congeners was significantly higher in the controls compared with endometriosis group. Women without C/C genotype in AhRR codon 185 had a significantly increased risk of endometriosis compared with those with C/C genotype. Total sum of the 12 congeners was significantly higher in women without C/C genotype compared with those with C/C genotype. Adjusting for age and AhRR codon 185 genotype, there was no significant association between exposure to PCBs and the risk of endometriosis. These findings suggest a possible presence of gene-environment interaction, however, we could not see any clear association between exposure to PCBs and the risk of endometriosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Ovarianas / Polimorfismo Genético / Bifenilos Policlorados / Endometriose Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans País como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Ovarianas / Polimorfismo Genético / Bifenilos Policlorados / Endometriose Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans País como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article