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Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia.
Luedtke, Daniel A; Su, Yongwei; Ma, Jun; Li, Xinyu; Buck, Steven A; Edwards, Holly; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H; White, Kathryn; Lin, Hai; Taub, Jeffrey W; Ge, Yubin.
Afiliação
  • Luedtke DA; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
  • Su Y; School of Life Sciences, Jilin University, 130021, Changchun, China.
  • Ma J; School of Life Sciences, Jilin University, 130021, Changchun, China.
  • Li X; School of Life Sciences, Jilin University, 130021, Changchun, China.
  • Buck SA; Division of Pediatric Hematology and Oncology, Children's Hospital of Michigan, Detroit, MI, USA, 48201.
  • Edwards H; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
  • Polin L; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
  • Kushner J; Molecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
  • Dzinic SH; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
  • White K; Molecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
  • Lin H; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
  • Taub JW; Molecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
  • Ge Y; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Signal Transduct Target Ther ; 5(1): 17, 2020 02 26.
Article em En | MEDLINE | ID: mdl-32296028
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Leucemia Mieloide Aguda / Compostos Bicíclicos Heterocíclicos com Pontes / Proteínas Proto-Oncogênicas c-bcl-2 / Quinase 9 Dependente de Ciclina / Proteína de Sequência 1 de Leucemia de Células Mieloides Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Leucemia Mieloide Aguda / Compostos Bicíclicos Heterocíclicos com Pontes / Proteínas Proto-Oncogênicas c-bcl-2 / Quinase 9 Dependente de Ciclina / Proteína de Sequência 1 de Leucemia de Células Mieloides Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article