Lipid mediators and sterile inflammation in ischemic stroke.
Int Immunol
; 32(11): 719-725, 2020 10 20.
Article
em En
| MEDLINE
| ID: mdl-32300780
ABSTRACT
Stroke is one of the major causes of lethality and disability, yet few effective therapies have been established for ischemic stroke. Inflammation in the ischemic brain is induced by the infiltration and subsequent activation of immune cells. Loss of cerebral blood flow and ischemic brain-cell death trigger the activation of infiltrating immune cells and drastic changes in the lipid content of the ischemic brain. In particular, polyunsaturated fatty acids and their metabolites regulate cerebral post-ischemic inflammation and ischemic stroke pathologies. In this review, we discuss the relationships between the lipid mediators and cerebral post-ischemic inflammation and their relevance to possible future therapeutic strategies targeting lipid mediators for ischemic stroke.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mediadores da Inflamação
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AVC Isquêmico
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Inflamação
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Lipídeos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article