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Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects.
Perli, Elena; Pisano, Annalinda; Pignataro, Maria Gemma; Campese, Antonio Francesco; Pelullo, Maria; Genovese, Ilaria; de Turris, Valeria; Ghelli, Anna Maria; Cerbelli, Bruna; Giordano, Carla; Colotti, Gianni; Morea, Veronica; d'Amati, Giulia.
Afiliação
  • Perli E; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
  • Pisano A; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
  • Pignataro MG; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
  • Campese AF; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Pelullo M; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.
  • Genovese I; Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Rome, Italy.
  • de Turris V; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.
  • Ghelli AM; Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, Italy.
  • Cerbelli B; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University, Latina, Italy.
  • Giordano C; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
  • Colotti G; Institute of Molecular Biology and Pathology, National Research Council of Italy, Rome, Italy.
  • Morea V; Institute of Molecular Biology and Pathology, National Research Council of Italy, Rome, Italy.
  • d'Amati G; Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
FASEB J ; 34(6): 7675-7686, 2020 06.
Article em En | MEDLINE | ID: mdl-32304340
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / RNA de Transferência / Doenças Mitocondriais / Membranas Mitocondriais / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / RNA de Transferência / Doenças Mitocondriais / Membranas Mitocondriais / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article