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A six-weekly dosing schedule for pembrolizumab in patients with cancer based on evaluation using modelling and simulation.
Lala, Mallika; Li, Tommy Ruosi; de Alwis, Dinesh P; Sinha, Vikram; Mayawala, Kapil; Yamamoto, Noboru; Siu, Lillian L; Chartash, Elliot; Aboshady, Hesham; Jain, Lokesh.
Afiliação
  • Lala M; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Li TR; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • de Alwis DP; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Sinha V; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Mayawala K; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Yamamoto N; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
  • Siu LL; University of Toronto, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Chartash E; Oncology Early Development, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Aboshady H; Clinical Safety and Risk Management, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Jain L; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address: lokesh_jain@merck.com.
Eur J Cancer ; 131: 68-75, 2020 05.
Article em En | MEDLINE | ID: mdl-32305010
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Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Humanizados / Antineoplásicos Imunológicos / Modelos Biológicos / Neoplasias Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Humanizados / Antineoplásicos Imunológicos / Modelos Biológicos / Neoplasias Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article