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Pharmacokinetics of maslinic and oleanolic acids from olive oil - Effects on endothelial function in healthy adults. A randomized, controlled, dose-response study.
de la Torre, Rafael; Carbó, Marceli; Pujadas, Mitona; Biel, Sarah; Mesa, María-Dolores; Covas, María-Isabel; Expósito, Manuela; Espejo, Juan-Antonio; Sanchez-Rodriguez, Estefanía; Díaz-Pellicer, Patricia; Jimenez-Valladares, Francisco; Rosa, Carmen; Pozo, Oscar; Fitó, Montserrat.
Afiliação
  • de la Torre R; Integrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Research Institute), Dr. Aiguader 88, 08003 Barcelona, Spain; UniversitatPompeuFabra (CEXS-UPF), Dr. Aiguader 88, 08003 Barcelona, Spain; CIBER de Fisiopatología Obesidad y Nutrición (CIBEROBN), Santiago de Comp
  • Carbó M; UniversitatPompeuFabra (CEXS-UPF), Dr. Aiguader 88, 08003 Barcelona, Spain. Electronic address: marcelli.carbo@upf.edu.
  • Pujadas M; Integrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Research Institute), Dr. Aiguader 88, 08003 Barcelona, Spain; CIBER de Fisiopatología Obesidad y Nutrición (CIBEROBN), Santiago de Compostela 15706, Spain. Electronic address: mpujadas@imim.es.
  • Biel S; Fundación Pública Andaluza para la Investigación Biosanitaria de Andalucía Oriental "Alejandro Otero" (FIBAO), Granada, Spain. Electronic address: sbiel@fibao.es.
  • Mesa MD; Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, Health Science Technological Park, University of Granada, Avenida del Conocimiento s/n. 18100 Armilla, Granada, Spain; Instituto de Investigación Biosanitariaibs
  • Covas MI; CIBER de Fisiopatología Obesidad y Nutrición (CIBEROBN), Santiago de Compostela 15706, Spain; NUPROAS (Nutritional Project Assessment), Handesbolag (NUPROAS HB), Nacka, Sweden.
  • Expósito M; Fundación Pública Andaluza para la Investigación Biosanitaria de Andalucía Oriental "Alejandro Otero" (FIBAO), Granada, Spain. Electronic address: manuela.exposito.ruiz.exts@juntadeandalucia.es.
  • Espejo JA; Instituto para la Calidad y Seguridad Alimentaria (ICSA), Granada, Spain.
  • Sanchez-Rodriguez E; Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, Health Science Technological Park, University of Granada, Avenida del Conocimiento s/n. 18100 Armilla, Granada, Spain.
  • Díaz-Pellicer P; Integrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Research Institute), Dr. Aiguader 88, 08003 Barcelona, Spain.
  • Jimenez-Valladares F; Cooperativa San Francisco de Asís. Montefrío. Granada, Spain. Electronic address: jvalladares@aceitesmontevilla.com.
  • Rosa C; Fundación Pública Andaluza para la Investigación Biosanitaria de Andalucía Oriental "Alejandro Otero" (FIBAO), Granada, Spain. Electronic address: crosa@fibao.es.
  • Pozo O; Integrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Research Institute), Dr. Aiguader 88, 08003 Barcelona, Spain. Electronic address: opozo@imim.es.
  • Fitó M; CIBER de Fisiopatología Obesidad y Nutrición (CIBEROBN), Santiago de Compostela 15706, Spain; Cardiovascular Risk and Nutrition Research Group, IMIM (Hospital del Mar Research Institute), Dr. Aiguader 88, 08003 Barcelona, Spain. Electronic address: mfito@imim.es.
Food Chem ; 322: 126676, 2020 Aug 30.
Article em En | MEDLINE | ID: mdl-32305871
To date, pharmacokinetics of maslinic (MA) and oleanolic (OA) acids, at normal dietary intakes in humans, have not been evaluated, and data concerning their bioactive effects are scarce. We assessed MA and OA pharmacokinetics after ingestion of olive oils (OOs) with high and low triterpenic acid contents, and specifically the effect of triterpenes on endothelial function. We performed a double-blind, dose-response, randomized, cross-over nutritional intervention in healthy adults, and observed that MA and OA increased in biological fluids in a dose-dependent manner. MA bioavailability was greater than that of OA, and consumption of pentacyclic triterpenes was associated with improved endothelial function. To the best of our knowledge, this is the first time MA pharmacokinetics, and effects on endothelial function in vivo, have been reported in humans.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oleanólico / Triterpenos / Azeite de Oliva Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oleanólico / Triterpenos / Azeite de Oliva Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article