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Characterization, bioavailability and protective effects of phenolic-rich extracts from almond hulls against pro-oxidant induced toxicity in Caco-2 cells.
An, Jun; Liu, Juer; Liang, Yuying; Ma, Yiwei; Chen, Chi; Cheng, Yanling; Peng, Peng; Zhou, Nan; Zhang, Renchuan; Addy, Min; Chen, Paul; Liu, Yuhuan; Huang, Guangwei; Ren, Difeng; Ruan, Roger.
Afiliação
  • An J; Beijing Key Laboratory of Forest Food Processing and Safety, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul 55108, USA.
  • Liu J; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul 55108, USA; Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, MN, USA.
  • Liang Y; Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, MN 55108, USA.
  • Ma Y; Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, MN, USA.
  • Chen C; Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, MN, USA.
  • Cheng Y; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul 55108, USA.
  • Peng P; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul 55108, USA.
  • Zhou N; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul 55108, USA.
  • Zhang R; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul 55108, USA.
  • Addy M; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul 55108, USA.
  • Chen P; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul 55108, USA.
  • Liu Y; State Key Laboratory of Food Science and Technology, and Engineering Research Center for Biomass Conversion, Ministry of Education, Nanchang University, Jiangxi 330047, China.
  • Huang G; Almond Board of California, 1150 9th Street, Suite 1500, Modesto, CA 95354, USA.
  • Ren D; Beijing Key Laboratory of Forest Food Processing and Safety, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China. Electronic address: rendifeng@bjfu.edu.cn.
  • Ruan R; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul 55108, USA; Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, MN, USA. Electronic address: ruanx001@umn.edu.
Food Chem ; 322: 126742, 2020 Aug 30.
Article em En | MEDLINE | ID: mdl-32305872
ABSTRACT
Almond hulls, the main by-product of almond production, are considered a valuable source of bioactive phenolic compounds. This study aimed to characterize the phenolic composition, bioavailability of the phenolic-rich extracts from almond hulls (PEAH), and their protective effect on oxidative stressed Caco-2 cells induced by tert-butylhydroperoxide (t-BOOH). The ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) analysis detected 11 phenolic compounds in the PEAH with high total phenolic content and antioxidant activity. Oxidative Caco-2 cell damage was reduced by PEAH, especially at 5 µg/mL, through scavenging reactive oxygen species (ROS), modulating the cellular endogenous antioxidant system and cell redox at a predictable status. Also, in vitro digestion influenced the phenolic compounds' composition and antioxidant power of PEAH. These results suggested that almond hulls, rich in phenolic compounds, can meliorate the oxidative stressed Caco-2 cells and restore its impaired redox balance, and ultimately improve health benefits.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenóis / Extratos Vegetais / Estresse Oxidativo / Substâncias Protetoras / Prunus dulcis Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenóis / Extratos Vegetais / Estresse Oxidativo / Substâncias Protetoras / Prunus dulcis Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article