Emerging Role of TRIM Family Proteins in Cardiovascular Disease.
Cardiology
; 145(6): 390-400, 2020.
Article
em En
| MEDLINE
| ID: mdl-32305978
ABSTRACT
Ubiquitination is one of the basic mechanisms of cell protein homeostasis and degradation and is accomplished by 3 enzymes, E1, E2, and E3. Tripartite motif-containing proteins (TRIMs) constitute the largest subfamily of RING E3 ligases, with >70 current members in humans and mice. These members are involved in multiple biological processes, including growth, differentiation, and apoptosis as well as disease and tumorigenesis. Accumulating evidence has shown that many TRIM proteins are associated with various cardiac processes and pathologies, such as heart development, signal transduction, protein degradation, autophagy mediation, ion channel regulation, congenital heart disease, and cardiomyopathies. In this review, we provide an overview of the TRIM family and discuss its involvement in the regulation of cardiac proteostasis and pathophysiology and its potential therapeutic implications.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article