Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively.

Yang, Cheng; Liao, Jianwen; Lai, Pinglin; Huang, Hai; Fan, Shicai; Chen, Yuhui; Bai, Xiaochun

Yang, Cheng; Liao, Jianwen; Lai, Pinglin; Huang, Hai; Fan, Shicai; Chen, Yuhui; Bai, Xiaochun.

Afiliação

Yang C; Academy of Orthopedics, Guangdong Province, Department of Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Liao J; Academy of Orthopedics, Guangdong Province, Department of Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Lai P; Academy of Orthopedics, Guangdong Province, Department of Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Huang H; Academy of Orthopedics, Guangdong Province, Department of Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Fan S; Academy of Orthopedics, Guangdong Province, Department of Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Chen Y; Academy of Orthopedics, Guangdong Province, Department of Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Bai X; Academy of Orthopedics, Guangdong Province, Department of Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.

Biomed Res Int ; 2020: 4572687, 2020.

Article em En | MEDLINE | ID: mdl-32309432

Assuntos

Células-Tronco Mesenquimais/metabolismo; Osteoblastos/metabolismo; Osteogênese/genética; Osteogênese/fisiologia; Proteína 1 do Complexo Esclerose Tuberosa/genética; Proteína 1 do Complexo Esclerose Tuberosa/metabolismo; Animais; Densidade Óssea; Desenvolvimento Ósseo/genética; Desenvolvimento Ósseo/fisiologia; Regulação da Expressão Gênica no Desenvolvimento; Proteínas de Homeodomínio/genética; Proteínas de Homeodomínio/metabolismo; Disco Intervertebral; Camundongos; Camundongos Knockout; Camundongos Transgênicos; Osteoblastos/patologia; Osteocalcina/genética; Osteocalcina/metabolismo; Transdução de Sinais; Esqueleto/diagnóstico por imagem; Esqueleto/patologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoblastos / Osteogênese / Células-Tronco Mesenquimais / Proteína 1 do Complexo Esclerose Tuberosa Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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