Novel cardiovascular biomarkers in patients with cardiovascular diseases undergoing intensive physical exercise.
Panminerva Med
; 62(3): 135-142, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32309918
ABSTRACT
BACKGROUND:
In this trial, we analyzed the plasma levels of novel biomarkers that reflect different pathophysiological pathways (sST2 mechanical strain, IGF-BP2 metabolic pathways, suPAR and GDF-15 inflammatory processes) in patients undergoing physical exercise to investigate the effects of training on their plasma concentrations.METHODS:
Plasma concentrations of novel biomarkers (sST2, IGF-BP2, suPAR and GDF-15) were analyzed by means of ELISA in patients with stable coronary artery disease (CAD) undergoing four weeks of high- and moderate-intensity training (EXCITE Trial) and in patients with one or more cardiovascular risk factors undergoing eight months of intensive physical exercise (IGF-BP2). Plasma levels of sST2 in patients undergoing eight months of intensive exercise have been published previously by our study group (1.13-fold change, P=0.045).RESULTS:
Four weeks of high-intensity exercise training resulted in a statistically significant change in the plasma level of sST2 (1.106-fold change, P=0.0054) and IGF-BP2 (1.24-fold-change, P=0.0165). Eight months of intensive exercise resulted in a significant increase of IGF-BP2 (median 61.2 ng/mL to 80.7 ng/mL, 1.319-fold change, P=0.006).CONCLUSIONS:
The significant increase of sST2 after four weeks might be a short-term effect due to the mechanical strain caused by the high-intensity training program, whereas the increase in IGF-BP2 after four weeks and eight months is likely a result of metabolic changes due to physical exercise.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Proteína 2 de Ligação a Fator de Crescimento Semelhante à Insulina
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Terapia por Exercício
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Proteína 1 Semelhante a Receptor de Interleucina-1
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Reabilitação Cardíaca
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article