Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.

Devos, Michael; Tanghe, Giel; Gilbert, Barbara; Dierick, Evelien; Verheirstraeten, Maud; Nemegeer, Josephine; de Reuver, Richard; Lefebvre, Sylvie; De Munck, Jolien; Rehwinkel, Jan; Vandenabeele, Peter; Declercq, Wim; Maelfait, Jonathan

Devos, Michael; Tanghe, Giel; Gilbert, Barbara; Dierick, Evelien; Verheirstraeten, Maud; Nemegeer, Josephine; de Reuver, Richard; Lefebvre, Sylvie; De Munck, Jolien; Rehwinkel, Jan; Vandenabeele, Peter; Declercq, Wim; Maelfait, Jonathan.

Afiliação

Devos M; VIB Center for Inflammation Research, Ghent, Belgium.
Tanghe G; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Gilbert B; VIB Center for Inflammation Research, Ghent, Belgium.
Dierick E; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Verheirstraeten M; VIB Center for Inflammation Research, Ghent, Belgium.
Nemegeer J; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
de Reuver R; VIB Center for Inflammation Research, Ghent, Belgium.
Lefebvre S; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
De Munck J; VIB Center for Inflammation Research, Ghent, Belgium.
Rehwinkel J; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Vandenabeele P; VIB Center for Inflammation Research, Ghent, Belgium.
Declercq W; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Maelfait J; VIB Center for Inflammation Research, Ghent, Belgium.

J Exp Med ; 217(7)2020 07 06.

Article em En | MEDLINE | ID: mdl-32315377

Assuntos

Inflamação/patologia; Queratinócitos/metabolismo; Queratinócitos/patologia; Necroptose; Ácidos Nucleicos/metabolismo; Proteínas de Ligação a RNA/metabolismo; Pele/patologia; Animais; Células HEK293; Humanos; Inflamação/imunologia; Interleucina-17/metabolismo; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteínas Quinases/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Ácidos Nucleicos / Queratinócitos / Proteínas de Ligação a RNA / Necroptose / Inflamação Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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