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Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes.
Hendriks, Delilah F G; Vorrink, Sabine U; Smutny, Tomas; Sim, Sarah C; Nordling, Åsa; Ullah, Shahid; Kumondai, Masaki; Jones, Barry C; Johansson, Inger; Andersson, Tommy B; Lauschke, Volker M; Ingelman-Sundberg, Magnus.
Afiliação
  • Hendriks DFG; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.
  • Vorrink SU; Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, The Netherlands.
  • Smutny T; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.
  • Sim SC; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.
  • Nordling Å; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.
  • Ullah S; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.
  • Kumondai M; Division of Clinical Pharmacology, Karolinska University Hospital Laboratory, Stockholm, Sweden.
  • Jones BC; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.
  • Johansson I; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
  • Andersson TB; DMPK, Oncology R&D, AstraZeneca, Cambridge, UK.
  • Lauschke VM; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.
  • Ingelman-Sundberg M; DMPK, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Clin Pharmacol Ther ; 108(4): 844-855, 2020 10.
Article em En | MEDLINE | ID: mdl-32320483
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatócitos / Citocromo P-450 CYP3A / Indutores do Citocromo P-450 CYP3A Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatócitos / Citocromo P-450 CYP3A / Indutores do Citocromo P-450 CYP3A Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article