Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae.
An Acad Bras Cienc
; 92(1): e20180595, 2020.
Article
em En
| MEDLINE
| ID: mdl-32321018
ABSTRACT
Pharmaceuticals occur in the environment due to their excessive consumption and the inefficiency of treatment plants to degrade, inactivate or remove them. Diazepam (DZP) stands out as the most consumed benzodiazepine, and induces sedative effects and reduces anxiety. Considering its potential appearance in several environmental compartments, the aim of the present study was to determine the effects of DZP under acute and chronic exposures on the mysid Mysidopsis juniae. Mortality was assessed using an acute toxicity test and a LC50 of 3.7 ± 0.5 mg·L-1was derived. The mass and length of the mysids was recorded in the chronic exposure to test for sublethal effects, and concentrations of 0.25 and 0.5 mg·L-1 of DZP affected mysids length and dry weight, respectively. Although effect-inducing concentrations used in this study are above environmentally relevant levels, the present study adds value to the limited available data for DZP toxicity to marine organisms, and we have shown that M. juniae is the most sensitive marine crustacean species tested thus far.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Crustáceos
/
Diazepam
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article